Clinical ethicists are often presented with the question: Is this plan or action ethical? The simple answer, which is as predictable as it is glib, is always: “it depends.” Recognizing and analyzin...

As the federal government distributed remdesivir to some of the states COVID-19 hit hardest, policymakers scrambled to develop criteria to allocate the drug to their hospitals. Our state, Michigan, was among those states to receive an initial quantity of the drug from the U.S. government. The disparities in burden of disease in Michigan are striking. Detroit has a death rate more than three times the state average. Our recommendation to the state was that it should prioritize the communities that bear (...) a disproportionate burden of suffering in the allocation of the new potential treatment. This recommendation is justified not only for new drugs with uncertain effects, but also for drugs of certain benefit or vaccines. For states with significant health disparities, such as Michigan, this allocation priority may help to repair them. In fact, any other allocation strategy may make them worse. (shrink)

Supernatural agent concepts are regarded as a defining trait of religion. The interaction of the minimally counterintuitive mnemonic effect and the hypersensitive agency detection device may be employed to explain the universal presence of concepts of gods and deities. Using the measure of free-recall, a broad model of cultural transmission investigated this pan-cultural transmission bias with a large age-representative sample in UK and China. Results were analyzed by four-way mixed ANOVA considering counterintuitiveness, familiarity, ontological category, and delay, and with age (...) as a covariate. A significant interaction of counterintuitiveness × HADD was found for both UK and China samples. These findings support assertions that supernatural agent concepts are more easily transmitted than other concepts because the present study finds that concepts similar to supernatural agents were more readily recalled. (shrink)

The field of clinical bioethics strongly advocates for the use of advance directives to promote patient autonomy, particularly at the end of life. This paper reports a study of clinical bioethicists’ perceptions of the professional consensus about advance directives, as well as their personal advance care planning practices. We find that clinical bioethicists are often sceptical about the value of advance directives, and their personal choices about advance directives often deviate from what clinical ethicists acknowledge to be their profession’s recommendations. (...) Moreover, our respondents identified a pluralistic set of justifications for completing treatment directives and designating surrogates, even while the consensus view focuses on patient autonomy. Our results suggest important revisions to academic discussion and public-facing advocacy about advance care planning. (shrink)

Graphical AbstractGene editing with engineered nucleases introduce double-strand breaks that are repaired by error-prone nonhomologous end-joining (NHEJ). In article number 1900126, Sara G. Trimidal et al. propose that the length and type or resulting indels can now be controlled by editing with different engineered nucleases or by manipulating the expression of NHEJ genes.

Genome editing with engineered nucleases (GEENs) introduce site‐specific DNA double‐strand breaks (DSBs) and repairs DSBs via nonhomologous end‐joining (NHEJ) pathways that eventually create indels (insertions/deletions) in a genome. Whether the features of indels resulting from gene editing could be customized is asked. A review of the literature reveals how gene editing technologies via NHEJ pathways impact gene editing. The survey consolidates a body of literature that suggests that the type (insertion, deletion, and complex) and the approximate length of indel edits (...) can be somewhat customized with different GEENs and by manipulating the expression of key NHEJ genes. Structural data suggest that binding of GEENs to DNA may interfere with binding of key components of DNA repair complexes, favoring either classical‐ or alternative‐NHEJ. The hypotheses have some limitations, but if validated, will enable scientists to better control indel makeup, holding promise for basic science and clinical applications of gene editing. Also see the video abstract here https://youtu.be/vTkJtUsLi3w. (shrink)

Machery & Mallon [The moral psychology handbook (pp. 3–47). New York, NY: Oxford University Press, 2010] argue that existing evidence does not support the claim that moral cognition, understood as a specific form of normative cognition, is a product of evolution. Instead, they suggest that the evidence only supports the more modest claim that a general capacity for normative cognition evolved. They argue that if this is the case then the prospects for evolutionary debunking arguments are bleak. A debunking argument (...) which relied on the fact that normative cognition in general evolved might threaten all areas of normative belief, including the epistemic norms upon which the argument relies. For the sake of argument, we accept their claim that specifically moral cognition did not evolve. However, we reject their contention that this critically undermines evolutionary debunking arguments of morality. A number of strategies are available to solve what we call the “containment problem,” or how to effectively debunk morality without thereby debunking normative cognition tout court. Furthermore, debunking arguments need not rely on the claim that normative cognition in general evolved. So long as at least some aspects of moral cognition have evolved, this may be sufficient to support an evolutionary debunking argument against many of our moral beliefs. Thus, even if Machery & Mallon are right that specifically moral cognition did not evolve, research in evolutionary psychology may have radical implications for moral philosophy. (shrink)

In 2016, a multidisciplinary body of scholars within the International Commission on Stratigraphy—the Anthropocene Working Group—recommended that the world officially recognize the Anthropocene as a new geological epoch. The most contested claim about the Anthropocene, that humans are a major geological and environmental force on par with natural forces, has proven to be a hotbed for discussion well beyond the science of geology. One reason for this is that it compels many natural and social scientists to confront problems and systems (...) that transgress traditional disciplinary boundaries, and as a result, calls for interdisciplinary research are now gaining traction. Proponents of such transgressions have dubbed the new scientific order that will result “Anthropocene Science”, and rhetoric notwithstanding, such discussions exemplify how recent changes within science justify rethinking a prevailing image of how science is done, and with it, the working relationship between scholars in the humanities, natural scientists, and social scientists. (shrink)

1. A multidisciplinary group of scholars within the International Commission on Stratigraphy – known as the Anthropocene Working Group – recently recommended the Anthropocene as a new geological ep...

Alzheimer’s disease (AD) in its most common form results in cognitive changes in memory function leading to dementia due to underlying neurodegenerative disease. Recent research advancements in AD...

SummaryThe incidence of family breakdown and stress has been examined in an unselected group of 92 South Wales families, each containing a patient suffering from Huntington's chorea, and related to the onset and duration of the disease, age of the patient, and behavioural symptoms shown. The frequency of actual and attempted suicide is analysed and the effects of the disorder on the primary care agent for the patient discussed. Some of the effects on children and the needs of the families (...) for support and practical help are outlined. It is concluded that family support is an essential factor in any programme aimed at the long-term alleviation and prevention of Huntington's chorea. (shrink)

This book breaks new ground for the philosophy of religion by showcasing work that engages with the lived reality of the spiritual life. It demonstrates that philosophy’s relationship with spirituality is more than a historical curiosity and that, in the twenty-first century, it is still meaningful to think about philosophy in connection with spirituality. The chapters are organised around the following themes: spiritual practice and philosophical understanding; philosophical reflections on living a spiritual life; philosophical problems concerning the spiritual life. The (...) first part discusses whether or not the topic of spirituality should be given a more fundamental role within the philosophy of religion, and, if so, how that might be accomplished. The second part addresses fundamental issues concerning human beings, their lives, and their self-understanding in relation to the spiritual life. The final part considers philosophical problems that emerge when discussing the spiritual life. By bringing together discussions of these topics this volume constitutes a valuable resource for scholars in disciplines in which the spiritual life is a focus of interest, particularly philosophy, theology, and religious studies. (shrink)

In this essay, I seek to enhance eschatological perspectives on work through specific engagement with Qoheleth’s theology of time in Eccl. 2–3. I suggest that prior to a perceptual transformation in the first of the book’s so-called carpe diem passages, Qoheleth is dissatisfied with his labour because he construes it temporally-speaking within a chronology characterised by competition. Within such a construal, death poses the ultimate obstacle to the enjoyment of labour, because it strips away the promise of an immortal inheritance (...) produced by human hands. What transforms Qoheleth’s relationship to labour is a new understanding of time as kairos, defined as the opportune time in which God unexpectedly intervenes in human work ‘under the sun’ and does something paradigmatically new. Under this ‘kairological’ perspective, Qoheleth assumes a posture of receipt, declaring present labour as a gift from God, with internal as well as external goods for the worker. Qoheleth’s ‘accipe diem work ethic’ draws the eschatological ultimacy of life and peace into present labour, re-orienting eschatological understandings of work that fall prey to competitive-chronological notions of progress. (shrink)

Dennett [1991] proposes a novel ontological account of the propositional attitudes—real patterns. Despite its name, the degree to which this account is committed to realism remains unclear. In this paper, I propose an alternative criterion of pattern instantiation, one that assesses the difficultly of faithfully interpreting a physical system as instantiating a particular pattern. Drawing on formal measures of simplicity and similarity, I argue that, for well-instantiated patterns, our interpretation will be computable by using a short program. This approach preserves (...) the flexibility of Dennett’s original, while offering substantially stronger realist commitments. (shrink)

In his recently published Where the Conflict Really Lies: Science, Religion, & Naturalism 2011 Alvin Plantinga criticises Paul Draper’s evolutionary argument against theism as part of a larger project to show that evolution poses no threat to Christian belief. Plantinga focuses upon Draper’s probabilistic claim that the facts of evolution are much more probable on naturalism than on theism, and with regard to that claim makes two specific points. First, Draper’s probabilistic claim contradicts theism’s necessary falsehood; unless Draper wishes to (...) acknowledge that theism is necessarily true, his claim commits him to theism’s contingency and so sets him at odds with a mainstream that sees God’s existence as decidedly noncontingent. Second, Plantinga argues that Draper’s probabilistic claim is, even if true, overwhelmed by counterclaims about facts that are more likely on theism than naturalism. I argue this critique of Draper depends upon a serious error, and that Plantinga overlooks the full implications of his own presuppositions. Correcting these shortcomings shows that Plantinga’s own probabilistic-apologetics (e.g., the ‘Evolutionary Argument Against Naturalism’) requires theism’s contingency no less than does Draper’s atheology. (shrink)

Fred Dretske, Michael Tooley, and David Armstrong accept a theory of governing laws of nature according to which laws are atomic states of affairs that necessitate corresponding natural regularities. Some philosophers object to the Dretske/Tooley/Armstrong theory on the grounds that there is no illuminating account of the necessary connection between governing law and natural regularity. In response, Michael Tooley has provided a reductive account of this necessary connection in his book Causation (1987). In this essay, I discuss an improved version (...) of his account and argue that it fails. First, the account cannot be extended to explain the necessary connection between certain sorts of laws—namely, probabilistic laws and laws relating structural universals—and their corresponding regularities. Second, Tooley’s account succeeds only by (very subtly) incorporating primitive necessity elsewhere, so the problem of avoiding primitive necessity is merely relocated. (shrink)

Locke’s argument for God’s immateriality in _Essay_ IV x is usually interpreted as involving a principle that in some way prohibits the causation of thought by matter. I reject these causal readings in favor of one that involves a principle which says a thinking being cannot be composed out of unthinking parts. This Composition Principle, as I call it, is crucial to understanding how Locke’s theistic argument can succeed in the face of his skepticism about the substance of matter and (...) the cause of thought, as well as his belief in the possibility of thinking matter. It also explains why Locke held the soul’s immateriality to be highly probable. (shrink)

Utility, rights, and holistic standards all point toward some modest steps to limit or check the predatory activity of carnivores relative to their victims. At the very least, we should limit current subsidies to nature’s carnivores. Policing nature need not be absurdly costly or violate common-sense intuitions.

This contribution aims at proposing a framework for articulating different kinds of “normativities” that are and can be attributed to “algorithmic systems.” The technical normativity manifests itself through the lineage of technical objects. The norm expresses a technical scheme’s becoming as it mutates through, but also resists, inventions. The genealogy of neural networks shall provide a powerful illustration of this dynamic by engaging with their concrete functioning as well as their unsuspected potentialities. The socio-technical normativity accounts for the manners in (...) which engineers, as actors folded into socio-technical networks, willingly or unwittingly, infuse technical objects with values materialized in the system. Surveillance systems’ design will serve here to instantiate the ongoing mediation through which algorithmic systems are endowed with specific capacities. The behavioral normativity is the normative activity, in which both organic and mechanical behaviors are actively participating, undoing the identification of machines with “norm following,” and organisms with “norminstitution”. This proposition productively accounts for the singularity of machine learning algorithms, explored here through the case of recommender systems. The paper will provide substantial discussions of the notions of “normative” by cutting across history and philosophy of science, legal, and critical theory, as well as “algorithmics,” and by confronting our studies led in engineering laboratories with critical algorithm studies. (shrink)

Do philosophic views affect job performance? The authors found that possessing a belief in free will predicted better career attitudes and actual job performance. The effect of free will beliefs on job performance indicators were over and above well-established predictors such as conscientiousness, locus of control, and Protestant work ethic. In Study 1, stronger belief in free will corresponded to more positive attitudes about expected career success. In Study 2, job performance was evaluated objectively and independently by a supervisor. Results (...) indicated that employees who espoused free will beliefs were given better work performance evaluations than those who disbelieve in free will, presumably because belief in free will facilitates exerting control over one’s actions. (shrink)

Tyler Burge presents a collection of his seminal essays on Gottlob Frege (1848-1925), who has a strong claim to be seen as the founder of modern analytic philosophy, and whose work remains at the centre of philosophical debate today. Truth, Thought, Reason gathers some of Burge's most influential work from the last twenty-five years, and also features important new material, including a substantial introduction and postscripts to four of the ten papers. It will be an essential resource for any (...) historian of modern philosophy, and for anyone working on philosophy of language, epistemology, or philosophical logic. (shrink)

We examine the ethical, social, and regulatory barriers that may hinder research on therapeutic potential of certain controversial controlled substances like marijuana, heroin, or ketamine. Hazards for individuals and society and potential adverse effects on communities may be good reasons for limiting access and justify careful monitoring of these substances. Overly strict regulations, fear of legal consequences, stigma associated with abuse and populations using illicit drugs, and lack of funding may, however, limit research on their considerable therapeutic potential. We review (...) the surprisingly sparse literature and address the particular ethical concerns pertinent to research with illicit and addictive substances, such as undue inducement, informed consent, therapeutic misconception, and risk to participants, researchers, and institutions. We consider the perspectives of key research stakeholders and explore whether they may be infected with bias. We conclude by proposing an empirical research agenda to provide an evidentiary basis for ethical reasoning. (shrink)

One reason to posit governing laws is to explain the uniformity of nature. Explanatory power can be purchased by accepting new primitives, and scientists invoke laws in their explanations without providing any supporting metaphysics. For these reasons, one might suspect that we can treat laws as wholly unanalyzable primitives. (John Carroll’s *Laws of Nature* (1994) and Tim Maudlin’s *The Metaphysics Within Physics* (2007) offer recent defenses of primitivism about laws.) Whatever defects primitive laws might have, explanatory weakness should not be (...) one of them. However, in this essay I’ll argue that wholly primitive laws cannot explain the uniformity of nature. The basic argument is based on the following idea: though a primitive law that P makes P likely, the primitive status of the law provides no reason to think that P must describe (or otherwise give rise to) a natural regularity. After identifying the problem for primitive laws, I consider an extension of the objection to all theories of governing laws and suggest that it may be avoided by a version of the Dretske/Tooley/Armstrong theory according to which laws are relations between universals. (shrink)

TWEEN POP examines the creation of the "tween" in the early 2000s as a gendered and raced consumer audience. The tween, aged nine to twelve, and usually thought of as a white girl, occupies a temporality between childhood and adolescence: she has aged out of children's products but is too young to fully engage in marketing directed at teenagers. But, as Tyler Bickford argues, this seemingly narrow market grew to broadly include four to fifteen year olds, with producers and (...) marketers pulling upwards and downwards by creating material that would attract younger viewers and teenagers, thereby creating a demographic that expanded, rather than limited, the traditional reach of child and teenage markets. According to Bickford, the key to this expansion was pop music, as it provided an intensity of experience that mirrored childhood in its investments in emotional authenticity, cultural value, and relational intimacies. In other words, pop music needed to be both intimate and public--a tension that Bickford argues defined the tween's positionality as well--and tween pop did so by pairing the mainstream pop of adulthood with images and lyrics suitable for younger audiences. Throughout the book, Bickford reveals how childhood's status as a private domestic position outside of politics was not a hindrance to the cultivation of children as a mass audience but rather was the very foundation of that project. By creating an intimate public of tween pop, the tween music industry was able to position tweens as still within the private domestic sphere of family life, but connected in a broader public of other tween-pop-listening tweens. Chapter 1 looks at Kidz Bop music videos to argue that the tween music industry framed childhood domesticity as complementary to participation in a public culture. Chapter 2 focuses on Disney Channel's popular music programs' efforts to engage older children, particularly older girls, in their marketing tactics. Chapter 3 analyzes the Disney Channel show Hannah Montana and its foregrounding of tensions between girlhood, public culture, and family. Chapter 4 attends to how whiteness served as central to the tween construction of innocence and childhood. Bickford concludes the book by periodizing the tween moment as the decade from 2001 to 2011, and then outlines the developments in popular culture for children since that time. This book will be of interest to students and scholars of ethnomusicology, feminism and gender studies, and cultural studies. (shrink)

This addendum expands upon the arguments made in the author’s 2020 essay, “Legal Personhood for Artificial Intelligence: Citizenship as the Exception to the Rule”, in an effort to display the significance human augmentation technologies will have on (feasibly) inadvertently providing legal protections to artificial intelligence systems (AIS)—a topic only briefly addressed in that work. It will also further discuss the impacts popular media have on imprinting notions of computerised behaviour and its subsequent consequences on the attribution of legal protections to (...) AIS and on speculative technological advancement that would aid the sophistication of AIS. (shrink)

On one thing the whole world seems to agree: Globalization is homogenizing cultures. At least, a lot of countries are acting as if that’s the case. In the name of containing what the Canadian novelist Margaret Atwood calls “the Great Star-Spangled Them,” the Canadian government subsidizes the nation’s film industry and requires radio stations to devote a percentage of their airtime to home-grown music, carving out extra airplay for stars such as Celine Dion and Barenaked Ladies. Ottawa also discouraged Borders, (...) the American book superstore, from entering the Canadian market out of fear that it would not carry enough Canadian literature. The French government spends some US $3 billion annually on culture and employs 12,000 cultural bureaucrats in an effort to preserve its vision of a uniquely French culture. Spain, South Korea and Brazil place binding domestic-content requirements on their cinemas; France and Spain do the same for television. Until recently, India barred the sale of Coca-Cola. (shrink)

The story of the Vox Populi embodies conflict theory, one popular interpretation of Marx's ideas, portraying a bloody revolution that loses sight of its ideals, turns anarchistic, and becomes the new oppressor. In Columbia, Zachary Hale Comstock and Jeremiah Fink illustrate the way the bourgeoisie may come to create and control the means of production. As the friction builds between the bourgeoisie and the proletariat, historical processes contribute to the inevitable collapse of capitalism. In BioShock Infinite, the simmering friction between (...) the upper and lower classes boils over into the rise of the Vox Populi. The functionalist perspective often casts religion as a social structure that keeps society together despite any negative costs it may have for any particular group. In order for the bourgeoisie to own the means of production and keep the working class oppressed, it uses propaganda and indoctrination as powerful agents of control. (shrink)

Marie was 15 when her abdominal pain began. After two years of negative work-ups, countless visits to gastroenterologists, and over 70 days of high school missed, she found herself readmitted to the hospital. “Refractory abdominal pain” was her ostensible diagnosis; “troubled teen” who was “going to be difficult” was embedded in the emergency department’s sign-out. When the medical team arrived to meet Marie, she was huddled in the corner of her hospital bed, silent and withdrawn. Her intern noted the numerous (...) scars cutting across her forearms as she felt for her radial pulses. Marie squirmed in pain when the intern palpated her abdomen.The ED’s work-up had been negative for abdominal pathology. When the... (shrink)

Challenging the dominant scholarly consensus that Nietzsche is simply an enemy of religion, Tyler Roberts examines the place of religion in Nietzsche's thought and Nietzsche's thought as a site of religion. Roberts argues that Nietzsche's conceptualization and cultivation of an affirmative self require that we interrogate the ambiguities that mark his criticisms of asceticism and mysticism. What emerges is a vision of Nietzsche's philosophy as the enactment of a spiritual quest informed by transfigured versions of religious tropes and practices. (...) Nietzsche criticizes the ascetic hatred of the body and this-worldly life, yet engages in rigorous practices of self-denial--he sees philosophy as such a practice--and affirms the need of imposing suffering on oneself in order to enhance the spirit. He dismisses the "intoxication" of mysticism, yet links mysticism, power, and creativity, and describes his own self-transcending experiences. The tensions in his relation to religion are closely related to that between negation and affirmation in his thinking in general. In Roberts's view, Nietzsche's transfigurations of religion offer resources for a postmodern religious imagination. Though as a "master of suspicion," Nietzsche, with Freud and Marx, is an integral part of modern antireligion, he has the power to take us beyond the flat, modern distinction between the secular and the religious--a distinction that, at the end of modernity, begs to be reexamined. (shrink)

The author responds to a letter by D. Brendan Johnson in the July‐August 2023 issue of the Hastings Center Report concerning his and Joseph Clair's article “Love Your Patient as Yourself: On Reviving the Broken Heart of American Medical Ethics.”.

I argue that, in light of his critique of rival theories of efficient causation, there is a puzzle latent in Aristotle’s own account. To show this, I consider one of his preferred examples of such causation, the activity of experts. Solving the puzzle yields a novel reading of Aristotle, one according to which experts, but not their characteristic arts or skills, are efficient causes.

According to best systems accounts, laws of nature are generalizations in the best systematization of particular matters of fact. Metrics such as simplicity and strength determine which systematization is best, but these are notoriously language relative. For this reason, David Lewis proposed a constraint on languages of inquiry: all predicates must be natural. This constraint is sometimes interpreted as requiring us to know which natural properties are instantiated in our world prior to scientific theorizing. I argue that this interpretation is (...) incorrect. I provide a better interpretation and show how it undercuts an influential epistemological objection to Lewis's best systems account of laws due to Bas van Fraassen. (shrink)

Cognition Through Understanding presents a selection of Tyler Burge's essays that use epistemology to illumine powers of mind. The essays focus on epistemic warrants that differ from those warrants commonly discussed in epistemology--those for ordinary empirical beliefs and for logical and mathematical beliefs. The essays center on four types of cognition warranted through understanding--self-knowledge, interlocution, reasoning, and reflection. Burge argues that by reflecting on warrants for these types of cognition, one better understands cognitive powers that are distinctive of persons, (...) and of human beings. The collection presents three previously unpublished independent essays, in addition to substantial, retrospective commentary. The retrospective commentary invites the reader to make connections that were not fully in mind when the essays were written. (shrink)

In this paper I aim to show why pediatric suffering must be understood as a judgment or evaluation, rather than a mental state. To accomplish this task, first I analyze the various ways that the label of suffering is used in pediatric practice. Out of this analysis emerge what I call the twin poles of pediatric suffering. At one pole sits the belief that infants and children with severe cognitive impairment cannot suffer because they are nonverbal or lack subjective life (...) experience. At the other pole exists the idea that once child suffering reaches some threshold it is ethical to eliminate the sufferer. Concerningly, at both poles, any particular child vanishes from view. Second, in an attempt to identify a theory of suffering inclusive of children, I examine two prominent so-called experiential accounts of suffering. I find them both wanting on account of their absurd entailments and their flawed assumptions regarding the subjective experiences of people who cannot communicate expressively. Finally, I extend arguments found in Alastair MacIntyre’s Dependent Rational Animals to argue that child suffering can be understood only as a set of absences—absences of conditions such as love, warmth, and freedom from pain. An evaluation of these absences reveals the exquisite dependency of children. It also discloses why pediatric suffering is necessarily a social and political event. Unlike adults, children will never be either the authors or the mitigators of their own suffering. Rather, children must rely wholly on others in order to resist suffering, grow, and flourish. (shrink)

In classical music, the immediate canon is Bach, Beethoven, Brahms, and Mozart. With Bach and Beethoven it is hard to go wrong. But my short list there would be Bach's B Minor Mass and St. Matthew's Passion, The Art of the Fugue, Well-Tempered Klavier, some of the organ music, the Brandenburgs, the Partitas, the Goldberg Variations, and the solo violin works.

If epistemology is roughly the study of knowledge, justification, warrant, and rationality, then religious epistemology is the study of how these epistemic concepts relate to religious belief and practice. This Element, while surveying various religious epistemologies, argues specifically for Plantingian religious epistemology. It makes the case for proper functionalism and Plantinga's AC models, while it also responds to debunking arguments informed by cognitive science of religion. It serves as a bridge between religious epistemology and natural theology.